Chemical Properties and Facts of 10191-41-0

Quality Control of DL-alpha-Tocopherol, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 10191-41-0.

We’ll be discussing some of the latest developments in chemical about CAS: 10191-41-0.10191-41-0, Name is DL-alpha-Tocopherol, molecular formula is C29H50O2, belongs to pyrrolines compound, is a common compound. In a patnet, author is La Fontaine, MA, once mentioned the new application about 10191-41-0, Quality Control of DL-alpha-Tocopherol.

Effect of exogenous and endogenous antioxidants on 3-nitropropionic acid-induced in vivo oxidative stress and striatal lesions: Insights into Huntington’s disease

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of complex ii in the mitochondria, 3-NP toxicity has gained acceptance as an animal model of Huntington’s disease (HD). In the present study, we confirmed that rats injected with 3-NP (20 mg/kg, i.p., daily for 4 days) exhibit increased oxidative stress in both striatum and cortical synaptosomes as well as lesions in the striatum, Synaptosomal membrane proteins from rats injected with 3-NP exhibited a decrease in W/S ratio, the relevant electron paramagnetic resonance (EPR) parameter used to determine levels of protein oxidation, and western blot analysis for protein carbonyls revealed direct evidence of increased synaptosomal protein oxidation. Treatment of rats with the brain-accessible free radical spin trap 5-diethoxyphosphoryl-5-methyl-1-pyrrolin N-oxide (DEPMPO; 30 mg/kg, i.p., daily 2 h before 3-NP injection) or with N-acetylcysteine (NAC; 100 mg/kg, i.p,, daily 2 h before 3-NP injection), a known glutathione precursor, before 3-NP treatments protects against oxidative damage induced by 3-NP as measured by EPR and western blot analysis for protein carbonyls, Furthermore, both DEPMPO and NAC treatments before 3-NP administration significantly reduce striatal lesion volumes. These data suggest oxidative damage is a prerequisite for striatal lesion formation and that antioxidant treatment may be a useful therapeutic strategy against 3-NP neurotoxicity and perhaps against HD as well.

Quality Control of DL-alpha-Tocopherol, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 10191-41-0.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem