Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 1953-02-2, Name is Tiopronin, molecular formula is C5H9NO3S, belongs to pyrrolines compound, is a common compound. In a patnet, author is Liu, Zhuqing, once mentioned the new application about 1953-02-2, COA of Formula: https://www.ambeed.com/products/1953-02-2.html.
Selective 1,4-Addition of Organolithiums to Maleate Monoesters with Application for a Short Efficient Route to Azaindanones
The ability of maleate half-ester salts to serve as electrophilic partners in 1,4-conjugate addition reactions with control of regioselectivity has previously been explored in only a limited context with soft nucleophiles. We have demonstrated that benzylic anions of picolines, as well as enolates of ketones, esters, and nitriles, react with lithium 4-( tert -butoxy)-4-oxobutenoate in a completely regioselective manner. This new method was applied to an expedient two-step process for preparing a key azaindanone intermediate for the clinical-candidate drug MK-8666.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1953-02-2. COA of Formula: https://www.ambeed.com/products/1953-02-2.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem