Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 578-95-0, Name is Acridin-9(10H)-one, molecular formula is , belongs to pyrrolines compound. In a document, author is Qiu, Xiao-Feng, SDS of cas: 578-95-0.
Late-Stage Transformation of Carboxylic Acids to N-Trifluoroethylimides with Trifluoromethyl Diazomethane
We report the first systematic evaluation of the reaction of trifluoromethyl diazomethane (2,2,2-trifluorodiazoethane, CF3CHN2) with drug-like molecules. We found our previous copper-catalyzed transformation of carboxylic acids to the corresponding N-trifluoroethylimides with CF3CHN2 and acetonitrile is well-suited for the latestage modification of drug and drug-like acids. A procedure that enables the use of solid nitriles and nitriles with high boiling points as viable substrates is also disclosed.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 578-95-0. SDS of cas: 578-95-0.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem