In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4. In an article, author is Zou, Shuping,once mentioned of 1977-07-7, Reference of 1977-07-7.
A integrated process for nitrilase-catalyzed asymmetric hydrolysis and easy biocatalyst recycling by introducing biocompatible biphasic system
The whole-cell nitrilase-catalyzed asymmetric hydrolysis of nitriles is a green and efficient preparation approach for chiral carboxylic acids, but often suffers from toxicity and cell lysis from organic substrates. In this work, a novel integrated process for whole-cell nitrilase-catalyzed asymmetric hydrolysis was developed for the first time by introducing a biocompatible ionic liquid (IL)-based biphasic system. The whole-cell nitrilases displayed an outstanding stability and recyclability in the biphasic system and still retained > 85% activity even after 7 cycles reaction. A preparative-scale fed-batch hydrolysis of o-chloromandelonitrile to (R)-o-chloromandelic acid (RCMA) was performed using the integrated process. The results revealed a yield of 91.3% and a space-time yield of 746.4 g.L-1.d(-1), which are currently the highest reported values for R-CMA biosynthesis. The proposed integrated process avoids substrate inhibition, facilitates the reusability of whole-cell nitrilases, and thus shows great potential for the sustainable production of chiral carboxylic acids.
Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 1977-07-7. Reference of 1977-07-7.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem