Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 1119-34-2, Name is Argininine monohydrochloride, molecular formula is C6H15ClN4O2, belongs to pyrrolines compound, is a common compound. In a patnet, author is PAIK, SG, once mentioned the new application about 1119-34-2, Category: pyrrolines.
MIRABIMIDE-E, AN UNUSUAL N-ACYLPYRROLINONE FROM THE BLUE-GREEN-ALGA SCYTONEMA MIRABILE – STRUCTURE DETERMINATION AND SYNTHESIS
Mirabimide E, a solid tumor selective cytotoxin from the terrestrial blue-green alga Scytonema mirabile UH strain BY-8-1, possesses an unprecedented tetrachlorinated ethylene group and has been identified as (5S,2’R,3’R)-N- (anti-8/,8′,9′,9′-tetrachloro-3′-(carbamoyloxy)-2′-methyldecanoyl)-4-methoxy-5-methyl-3-pyrrolin-2-one. The total structure, including absolute stereochemistry, of this novel N-acylpyrrolinone was concluded from a combination of spectral and chemical studies, including stereoselective syntheses of three degradation products, viz. methyl (2R,3R)-anti-8,8,9,9-tetrachloro-3-hydroxy-2-methyldecanoate, (5R,6R)-trans-5-methyl-6-(5,5′,6,6′-tetrachloroheptyl-1-oxa- 3-azacyclohexane-2,4-dione, and (5S)-4-methoxy-5-methyl-3-pyrrolin-2-one and the total synthesis of mirabimide E itself. The influence of the carbamate ester group on the chemical degradation and synthesis of mirabimide E is described.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 1119-34-2. Category: pyrrolines.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem