You could be based in a university, combining chemical research with teaching; working on developing and trialing new drugs; or helping to ensure national healthcare provision keeps pace with new discoveries. 38609-97-1, Name is 2-(9-Oxoacridin-10(9H)-yl)acetic acid, molecular formula is C15H11NO3, belongs to pyrrolines compound, is a common compound. In a patnet, author is Feberero, Claudia, once mentioned the new application about 38609-97-1, Electric Literature of 38609-97-1.
Experimental and Computational Study of the 1,5-O -> N Carbamoyl Snieckus-Fries-Type Rearrangement
The reactions of o-lithiated O-aryl N,N-diethylcarbamates with different C-N multiple bond electrophiles have been thoroughly studied. A 1,5-O -> N carbamoyl shift, a new variation of the anionic Fries-type rearrangement, takes place when nitriles, imines, or alkylcarbodiimides are employed. In these cases, the carbamoyl group plays a dual role as a directing group, building up a variety of functional groups through the 1,5-O -> N carbamoyl migration. On the other hand, the use of iso(thio)cyanates and arylcarbodiimides led to non-rearranged o-functionalized O-arylcarbamates. This reactivity was further computationally explored, and the governing factor could be traced back to the relative basicity of the alternative products (migrated vs nonmigrated substrates). This exploration also provided interesting insights about the degree of complexation of the lithium cations onto these substrates. A new access to useful 2-hydroxybenzophenone derivatives has also been developed.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem