We’ll be discussing some of the latest developments in chemical about CAS: 274-09-9.274-09-9, Name is Benzo[d][1,3]dioxole, molecular formula is C7H6O2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Dairi, Kenza, once mentioned the new application about 274-09-9, Synthetic Route of 274-09-9.
A scalable process for the synthesis of the bcl inhibitor obatoclax
Recently we created the novel indolylprodigiosin derivative 2 (obatoclax) and demonstrated its ability to antagonize multiple members of the B-cell lymphoma (Bcl) family of antiapoptotic proteins. The compound has shown potent anticancer activity in several animal tumor models. Obatoclax is now in Phase 1b and 2 clinical trials directed against multiple hematologic and solid tumor malignancies. To support its clinical development, a new scalable synthesis was required. Obatoclax has been prepared using a three-step synthesis, starting from commercially available 4-methoxy-3-pyrrolin-2-one. The reaction sequence involves a haloformylation reaction followed by a Suzuki cross-coupling reaction with an indole-2-boronic acid. The synthesis is completed by an acid-mediated condensation with 2,4-dimethyl-1H-pyrrole.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 274-09-9, you can contact me at any time and look forward to more communication. Synthetic Route of 274-09-9.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem