The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. 636-41-9, Name is 2-Methyl-1H-pyrrole, molecular formula is C5H7N, belongs to pyrrolines compound, is a common compound. In a patnet, author is Trost, Barry M., once mentioned the new application about 636-41-9, Application In Synthesis of 2-Methyl-1H-pyrrole.
Synthesis of Chiral, Densely Substituted Pyrrolidones via Phosphine-Catalyzed Cycloisomerization
Densely substituted chiral pyrrolidones are synthesized via phosphine-catalyzed cycloisomerization of enantioenriched beta-amino ynones, which are prepared in a single step using a highly enantioselective Zn-ProPhenol-catalyzed Mannich reaction. The exocyclic alkenes in the cyclization products provide versatile handles for further transformations and typically form with good E/Z selectivity. This cycloisomerization method can be performed in streamlined fashion, without purification of the intermediate Mannich adduct, and extends to anthranilic acid based scaffolds in addition to ProPhenol-derived Mannich adducts.
Application In Synthesis of 2-Methyl-1H-pyrrole, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 636-41-9 is helpful to your research.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem