Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 930-88-1, Name is 1-Methyl-1H-pyrrole-2,5-dione, molecular formula is C5H5NO2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Ricko, Sebastijan, once mentioned the new application about 930-88-1, Formula: https://www.ambeed.com/products/930-88-1.html.
Double Spirocyclization of Arylidene-Delta(2)-Pyrrolin-4-Ones with 3-Isothiocyanato Oxindoles
Arylidene-Delta(2)-pyrrolin-4-ones undergo organocatalyzed double spirocyclization with 3-isothiocianato oxindoles in a domino 1,4/1,2-addition sequence. The products contain three contiguous stereocenters (ee up to 98%, dr up to 99:1, 12 examples). The absolute configuration of the major diastereomer was determined by single crystal X-ray analysis. Along with heterocyclic Michael acceptors based on oxazolone, isoxazolone, thiazolidinone, pyrazolone, and pyrimidinedione, the reported results display the applicability of unsaturated Delta(2)-pyrrolin-4-ones (pyrrolones) for the organocatalyzed construction of 3D-rich pyrrolone-containing heterocycles.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem