Formula: https://www.ambeed.com/products/1953-02-2.html, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 1953-02-2, Name is Tiopronin, SMILES is O=C(O)CNC(C(S)C)=O, belongs to pyrrolines compound. In a article, author is Zhao, Xiaoyuan, introduce new discover of the category.
TBHP/TBAI-Mediated Oxidative Cascade Reaction Consisting of Dimerization, Cyclization, and 1,2-Aryl Migration: Metal-Free Synthesis of Pyrrolin-4-ones and Highly Substituted Pyrroles
Treatment of enamino esters with TBHP (t-butylhydroperoxide) and TBAI (t-butylammonium iodide) in HFIP (hexafluoroisopropanol) was found to afford a variety of substituted pyrrolin-4-one compounds. This metal-free oxidative cascade reaction consists of the key steps of coupling of two radical intermediates, an intramolecular ring closure, and an exclusive 1,2-aryl radical migration. Upon treatment with a base, the obtained pyrrolin-4-ones could be converted to the highly substituted pyrrole compounds.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem