The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. 930-88-1, Name is 1-Methyl-1H-pyrrole-2,5-dione, molecular formula is C5H5NO2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Khramtsov, V, once mentioned the new application about 930-88-1, HPLC of Formula: https://www.ambeed.com/products/930-88-1.html.
NMR spin trapping: Detection of free radical reactions using a phosphorus-containing nitrone spin trap
This study employs P-31-nuclear magnetic resonance (NMR) to probe for changes in molecular structure arising from reactions between free radicals and a phosphorus-containing nitrone spin trap, 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide (DEPMPO), A number of biologically relevant free radical reactions were detected: a) reactions of DEPMPO with OH resulted in a new P-31-NMR resonance at 27.05 ppm (shifted from the parent compound at 23.67 ppm); evidence suggests that this species is a diamagnetic hydroxy-pyrrolidone reduction product; b) P-31-NMR spectra of DEPMPO/(CH3)-C-. reactions resulted in peaks at 24.54, 30.83, and 32.31 ppm, while DEPMPO/(CH2OH)-C-. produced peaks at 24.05, 30.80 and 32.52 ppm; in the presence of excess ascorbate, only resonances between 30 and 32 ppm were evident, which we have tentatively assigned to the hydroxylamine isomers of their respective adducts; and c) reaction of DEPMPO with O-2(.-), produced by xanthine/xanthine oxidase or stimulated neutrophils, resulted in a single line, indistinguishable from DEPMPO/(OH)-O-. reaction products, We conclude that NMR spin trapping is a useful approach for detecting free radical reaction pathways. It may have future applications for human free radical biology and imaging. Magn Reson Med 42:228-234, 1999. (C) 1999 Wiley-Liss, Inc.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem