Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, and are directly involved in the process of chemical products and materials. 578-95-0, Name is Acridin-9(10H)-one, molecular formula is , belongs to pyrrolines compound. In a document, author is Lu, Yi, COA of Formula: https://www.ambeed.com/products/578-95-0.html.
A new process for the synthesis of nafoxidene as a key intermediate of lasofoxifene
A novel brief process for the synthesis of nafoxidene has been developed. The epoxidation of 6-methoxy-1-{4-[2-(pyrrolin-1-yl)ethoxy)]phenyl}-3,4-dihydronaphthalene by m-CPBA directly gave the ketone 6-methoxy-1-[4-(2-(pyrrolidin-1-yl)ethoxy) phenyl]-3,4-dihydronaphthalen-2(1H)-one, which was subject to phenyl magnesium bromide/cerium chloride and subsequently treated with an acid to yield nafoxidene. In addition, the preparation of the starting naphthalene was also optimized by replacing the aromatic lithium at low temperature with its Grignard reagent at refluxing THF. This mild process, without the use of toxic or noble metals, was more cost-efficient and easily worked up.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem