Computed Properties of C5H3ClFN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles. Author is Shaw, Megan H.; Shurtleff, Valerie W.; Terrett, Jack A.; Cuthbertson, James D.; MacMillan, David W. C..
The use of sp3 C-H bonds-which are ubiquitous in organic mols.-as latent nucleophile equivalent for transition metal-catalyzed cross-coupling reactions has the potential to substantially streamline synthetic efforts in organic chem. while bypassing substrate activation steps. Through the combination of photoredox-mediated hydrogen atom transfer (HAT) and nickel catalysis, we have developed a highly selective and general C-H arylation protocol that activates a wide array of C-H bonds as native functional handles for cross-coupling. This mild approach takes advantage of a tunable HAT catalyst that exhibits predictable reactivity patterns based on enthalpic and bond polarity considerations to selectively functionalize α-amino and α-oxy sp3 C-H bonds in both cyclic and acyclic systems.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem