The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,6-Dichloro-3-fluoropyridine( cas:52208-50-1 ) is researched.HPLC of Formula: 52208-50-1.Remuzon, Philippe; Bouzard, Daniel; Jacquet, Jean Pierre published the article 《Preparation of new 2-chloro-5-fluoro-6-[(4-phenylmethyl)piperazinyl]-4-trifluoromethyl-3-nicotinic acid》 about this compound( cas:52208-50-1 ) in Heterocycles. Keywords: nicotinic acid piperazinyl trifluoromethyl preparation antibacterial; fluoroacetate condensation ethyl trifluoroacetate; pyridone preparation chlorination. Let’s learn more about this compound (cas:52208-50-1).
The nicotinic acid (I), which could be a key intermediate for novel potential antibacterial 1,8-naphthyridine-3-carboxylic acid analogs, was prepared starting with construction of the pyridine nucleus of II by Et 2-fluoroacetate and Et 2-trifluoroacetate.
From this literature《Preparation of new 2-chloro-5-fluoro-6-[(4-phenylmethyl)piperazinyl]-4-trifluoromethyl-3-nicotinic acid》,we know some information about this compound(52208-50-1)HPLC of Formula: 52208-50-1, but this is not all information, there are many literatures related to this compound(52208-50-1).
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem