Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Structural and stereoisomeric specificity of serum-borne sugar acids related to feeding control by rats.
Specificity of chem. structures and stereoisomers among serum-borne short-chain organic acids in rats were assessed for their effects on feeding behavior and humoral factors by infusion into the rat 3rd cerebroventricle. Infusion of glyceric acid (1.0 μmol), 3,4-dihydroxybutanoic acid γ-lactone (3,4-DB), or 3,4,5-trihydroxypentanoic acid γ-lactone (2.50 μmol) immediately before the dark phase decreased food intake for, at most, 24 h. These acids did not affect drinking or ambulation. Initial feeding, not necessarily accompanied by periprandial drinking, was induced after infusion of 2,4-dihydroxy-butanoic acid γ-lactone, 2,4,5-trihydroxypentanoic acid γ-lactone (2,4,5-TP), or exogenous 2,4,5,6-tetrahydroxyhexanoic acid γ-lactone (2.50 μmol) in the light phase. Of these acids, 3,4-DB most potently suppressed and 2,4,5-TP most potently enhanced feeding. Of these, the 2S,4S-isomer and the 3S-isomer were the most potent of 2,4,5-TP and 3,4-DB, resp. Only the 2S,4S-isomer of 2,4,5-TP induced hypoglycemia with hyperinsulinemia, whereas opposite effects were produced by the 3S-isomer of 3,4-DB. The positions of the hydroxyl groups on 4-butanolide and the S- and S,S-stereoisomers are important in modulating food intake through the hypothalamus.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem