Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Research Support, Non-U.S. Gov’t, Organic & Biomolecular Chemistry called Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines, Author is Lu, Ju-You; Zhao, Bo; Du, Yongmei; Yang, Jianxin; Lu, Jian, the main research direction is transition metal free nucleophilic substitution carboranyl lithium halopyridine; pyridinyl carborane preparation.Recommanded Product: 4-Chloro-2-fluoropyridine.
A practical and efficient C(cage)-heteroarylation of carborane is presented, via direct nucleophilic substitution of carboranyllithium with 2-halopyridines. This reaction does not need the aid of any transition metal and utilizes readily available carboranyllithium nucleophiles, thereby avoiding transmetalation of carboranyllithium. The process exhibits a broad scope, and a vast array of 2-halopyridines have proven to be suitable substrates. The method serves as a complement to C(cage)-arylation reactions and may find wide applications in materials science and medicinal and coordination chem.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem