So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ishibashi, Fumito; Hayashita, Mami; Okazaki, Momotoshi; Shuto, Yoshihiro researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Quality Control of (R)-4-Hydroxydihydrofuran-2(3H)-one.They published the article 《Improved procedure for the enantiomeric synthesis of 1-hydroxy/acetoxy-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans: total syntheses of (+)-paulownin, (+)-phrymarin I and (+)-phrymarin II》 about this compound( cas:58081-05-3 ) in Bioscience, Biotechnology, and Biochemistry. Keywords: lignan paulownin phrymarin enantiomeric synthesis photocyclization. We’ll tell you more about this compound (cas:58081-05-3).
Short enantiomeric syntheses of the 1-hydroxy/acetoxy-3,7-dioxabicyclo[3.3.0]octane lignans, (+)-paulownin (I, R1 = R2 = R3 = H), and (+)-phrymarin I (I, R1 = R2 = OMe, R3 = Ac) and II (I, R1 = OMe, R2 = H, R3 = Ac), were accomplished by starting from the chiral synthon, (R)-(+)-3-hydroxybutanolide, and employing photocyclization as the key step.
I hope my short article helps more people learn about this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Quality Control of (R)-4-Hydroxydihydrofuran-2(3H)-one. Apart from the compound(58081-05-3), you can read my other articles to know other related compounds.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem