The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Chloro-2-fluoropyridine( cas:34941-92-9 ) is researched.Safety of 4-Chloro-2-fluoropyridine.Jin, Hao; Gao, Zhuo; Zhou, Shaodong; Qian, Chao published the article 《One-Pot Approach for SNAr Reaction of Fluoroaromatic Compounds with Cyclopropanol》 about this compound( cas:34941-92-9 ) in Synlett. Keywords: aryl cyclopropyl ether preparation; fluoroarom compound cyclopropanol nucleophilic aromatic substitution. Let’s learn more about this compound (cas:34941-92-9).
A novel method for preparation of aryl cyclopropyl ethers I [Ar = 1-ClC6H4, 2-O2NC6H4, 4-chloro-2-pyridyl, etc.] via nucleophilic aromatic substitution reaction (SNAr) of fluoroarom. compounds with cyclopropanol under relatively mild conditions was developed. The reaction was performed at 75 °C with Cs2CO3 as the base and DMF as solvent, after 6 h the yield was up to 90%. Finally, various fluoroarom. compounds were employed as substrates for a test that proved a wide application scope of the method.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem