Brief introduction of 34941-92-9

From this literature《Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy》,we know some information about this compound(34941-92-9)Safety of 4-Chloro-2-fluoropyridine, but this is not all information, there are many literatures related to this compound(34941-92-9).

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Chloro-2-fluoropyridine(SMILESS: ClC1=CC(=NC=C1)F,cas:34941-92-9) is researched.Synthetic Route of C16H16Cl2Cu2. The article 《Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:34941-92-9).

Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interest as a target for inhibition due to its implication in neuropathic pain and respiratory disease. Herein, we describe the optimization of a series of potent, selective, and orally bioavailable TRPA1 small mol. antagonists, leading to the discovery of a novel tetrahydrofuran-based linker. Given the balance of physicochem. properties and strong in vivo target engagement in a rat AITC-induced pain assay, compound (I) was progressed into a guinea pig ovalbumin asthma model where it exhibited significant dose-dependent reduction of inflammatory response. Furthermore, the structure of the TRPA1 channel bound to compound (II) was determined via cryogenic electron microscopy to a resolution of 3 Å, revealing the binding site and mechanism of action for this class of antagonists. Tetrahydrofurans

From this literature《Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy》,we know some information about this compound(34941-92-9)Safety of 4-Chloro-2-fluoropyridine, but this is not all information, there are many literatures related to this compound(34941-92-9).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The important role of 52208-50-1

From this literature《Preparation of new 2-chloro-5-fluoro-6-[(4-phenylmethyl)piperazinyl]-4-trifluoromethyl-3-nicotinic acid》,we know some information about this compound(52208-50-1)HPLC of Formula: 52208-50-1, but this is not all information, there are many literatures related to this compound(52208-50-1).

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,6-Dichloro-3-fluoropyridine( cas:52208-50-1 ) is researched.HPLC of Formula: 52208-50-1.Remuzon, Philippe; Bouzard, Daniel; Jacquet, Jean Pierre published the article 《Preparation of new 2-chloro-5-fluoro-6-[(4-phenylmethyl)piperazinyl]-4-trifluoromethyl-3-nicotinic acid》 about this compound( cas:52208-50-1 ) in Heterocycles. Keywords: nicotinic acid piperazinyl trifluoromethyl preparation antibacterial; fluoroacetate condensation ethyl trifluoroacetate; pyridone preparation chlorination. Let’s learn more about this compound (cas:52208-50-1).

The nicotinic acid (I), which could be a key intermediate for novel potential antibacterial 1,8-naphthyridine-3-carboxylic acid analogs, was prepared starting with construction of the pyridine nucleus of II by Et 2-fluoroacetate and Et 2-trifluoroacetate.

From this literature《Preparation of new 2-chloro-5-fluoro-6-[(4-phenylmethyl)piperazinyl]-4-trifluoromethyl-3-nicotinic acid》,we know some information about this compound(52208-50-1)HPLC of Formula: 52208-50-1, but this is not all information, there are many literatures related to this compound(52208-50-1).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Some scientific research about 34941-92-9

From this literature《Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles》,we know some information about this compound(34941-92-9)Computed Properties of C5H3ClFN, but this is not all information, there are many literatures related to this compound(34941-92-9).

Computed Properties of C5H3ClFN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles. Author is Shaw, Megan H.; Shurtleff, Valerie W.; Terrett, Jack A.; Cuthbertson, James D.; MacMillan, David W. C..

The use of sp3 C-H bonds-which are ubiquitous in organic mols.-as latent nucleophile equivalent for transition metal-catalyzed cross-coupling reactions has the potential to substantially streamline synthetic efforts in organic chem. while bypassing substrate activation steps. Through the combination of photoredox-mediated hydrogen atom transfer (HAT) and nickel catalysis, we have developed a highly selective and general C-H arylation protocol that activates a wide array of C-H bonds as native functional handles for cross-coupling. This mild approach takes advantage of a tunable HAT catalyst that exhibits predictable reactivity patterns based on enthalpic and bond polarity considerations to selectively functionalize α-amino and α-oxy sp3 C-H bonds in both cyclic and acyclic systems.

From this literature《Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles》,we know some information about this compound(34941-92-9)Computed Properties of C5H3ClFN, but this is not all information, there are many literatures related to this compound(34941-92-9).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Simple exploration of 4045-24-3

From this literature《Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors》,we know some information about this compound(4045-24-3)COA of Formula: C6H13NO, but this is not all information, there are many literatures related to this compound(4045-24-3).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors, published in 2021-01-01, which mentions a compound: 4045-24-3, Name is 4-Methoxypiperidine, Molecular C6H13NO, COA of Formula: C6H13NO.

As abnormal PI3K signaling is a feature of many types of cancer, the development of orally active PI3K inhibitors is of great significance for targeted cancer therapy. Through integrating strategies of reducing aromatic character/increasing the fraction of sp3 carbons together with scaffold hopping, we designed and synthesized two new series of thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives for use as PI3K inhibitors. Our structure-activity relationship studies led to the identification of thieno[2,3-d]pyrimidine 6a and thiazolo[5,4-d]pyrimidine 7a (I and II, resp.), which exhibited remarkable nanomolar PI3K potency, good antiproliferative activity, favorable pharmacokinetic properties and significant in vivo anti-cancer efficacy. Notably, thiazolo[5,4-d]pyrimidine 7a had better anti-cancer activity than thieno[2,3-d]pyrimidine 6a and is worthy of further pre-clin. evaluation for its use in cancer treatment.

From this literature《Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors》,we know some information about this compound(4045-24-3)COA of Formula: C6H13NO, but this is not all information, there are many literatures related to this compound(4045-24-3).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Derivation of elementary reaction about 136663-38-2

From this literature《Palladium-Catalyzed Direct Hydroxymethylation of Aryl Halides and Triflates with Potassium Acetoxymethyltrifluoroborate》,we know some information about this compound(136663-38-2)Name: (2-Methylbenzo[d]oxazol-5-yl)methanol, but this is not all information, there are many literatures related to this compound(136663-38-2).

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2-Methylbenzo[d]oxazol-5-yl)methanol, is researched, Molecular C9H9NO2, CAS is 136663-38-2, about Palladium-Catalyzed Direct Hydroxymethylation of Aryl Halides and Triflates with Potassium Acetoxymethyltrifluoroborate.Name: (2-Methylbenzo[d]oxazol-5-yl)methanol.

Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.

From this literature《Palladium-Catalyzed Direct Hydroxymethylation of Aryl Halides and Triflates with Potassium Acetoxymethyltrifluoroborate》,we know some information about this compound(136663-38-2)Name: (2-Methylbenzo[d]oxazol-5-yl)methanol, but this is not all information, there are many literatures related to this compound(136663-38-2).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Discovery of 34941-92-9

From this literature《Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts》,we know some information about this compound(34941-92-9)COA of Formula: C5H3ClFN, but this is not all information, there are many literatures related to this compound(34941-92-9).

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Journal of Organic Chemistry called Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts, Author is Kinens, Artis; Balkaitis, Simonas; Suna, Edgars, the main research direction is scalable synthesis chiral Vedejs type DMAP catalyst; amination pyridine zinc amine complex; mechanistic study zinc facilitated nucleophilic aromatic substitution.COA of Formula: C5H3ClFN.

A scalable synthesis of chiral Vedejs-type DMAP catalysts is reported. The key step of the synthesis is amination of the enantiomerically pure 4-chloropyridine derivative using well-defined ZnCl2(amine)2 complexes. A series of Zn(II)-amine complexes have been synthesized to explore the scope of the ZnCl2-mediated amination of 4-halopyridines. Mechanistic studies support a Zn(II)-facilitated nucleophilic aromatic substitution as a plausible mechanism for the chlorine-to-amine exchange.

From this literature《Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts》,we know some information about this compound(34941-92-9)COA of Formula: C5H3ClFN, but this is not all information, there are many literatures related to this compound(34941-92-9).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Research on new synthetic routes about 4045-24-3

From this literature《Orally bioavailable HCV NS5A inhibitors of unsymmetrical structural class》,we know some information about this compound(4045-24-3)Product Details of 4045-24-3, but this is not all information, there are many literatures related to this compound(4045-24-3).

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Orally bioavailable HCV NS5A inhibitors of unsymmetrical structural class, the main research direction is bioavailability HCV NS5A inhibitor solubility permeability; Antiviral; HCV; NS5A; Oral bioavailability; Unsynmmetrical structure.Product Details of 4045-24-3.

A novel unsym. structural class of orally bioavailable hepatitis C virus (HCV) nonstructural 5A protein (NS5A) inhibitors has been generated by improving both the solubility and membrane permeability of the lead compound found in our previous work. The representative compound 14, with a 5-hydroxymethylpyrazine group and a 3-t-butylpropargyl group on each side of the mol., exhibited the best oral bioavailability in this study, inhibiting not only the HCV genotype 1a, 1b, 2a, and 3a replicons with EC50 values in the picomolar range, but also inhibited 1a Q30 mutants induced by launched sym. inhibitors with EC50 values in the low nanomolar range.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Downstream Synthetic Route Of 59782-89-7

From this literature《First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump》,we know some information about this compound(59782-89-7)Category: pyrrolines, but this is not all information, there are many literatures related to this compound(59782-89-7).

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 59782-89-7, is researched, SMILESS is CC1=CC(I)=CN=C1Cl, Molecular C6H5ClINJournal, Article, Journal of Medicinal Chemistry called First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump, Author is Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain, the main research direction is boron compound transport protein NorA Staphylococcus.Category: pyrrolines.

Overexpression of efflux pumps is an important mechanism of bacterial resistance that results in the extrusion of antimicrobial agents outside the bacterial cell. Inhibition of such pumps appears to be a promising strategy that could restore the potency of existing antibiotics. The NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrates, such as hydrophilic fluoroquinolones, leading to a multidrug-resistance phenotype. Here, 150 heterocyclic boronic species were evaluated for their activity against susceptible and resistant strains of S. aureus. Twenty-four hit compounds, although inactive when tested alone, were found to potentiate ciprofloxacin activity by a 4-fold increase at concentrations ranging from 0.5 to 8 μg/mL against S. aureus 1199B, which overexpresses NorA. Boron-free analogs showed no biol. activity, thus revealing that the boron atom is crucial for biol. activity. This work describes the first reported efflux pump inhibitory activity of boronic acid derivatives

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Application of 58081-05-3

From this literature《Synthesis of nature product kinsenoside analogues with anti-inflammatory activity》,we know some information about this compound(58081-05-3)Synthetic Route of C4H6O3, but this is not all information, there are many literatures related to this compound(58081-05-3).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of nature product kinsenoside analogues with anti-inflammatory activity, published in 2021-01-01, which mentions a compound: 58081-05-3, Name is (R)-4-Hydroxydihydrofuran-2(3H)-one, Molecular C4H6O3, Synthetic Route of C4H6O3.

Kinsenoside (I) is a major bioactive component in herbal medicines that possesses a broad range of pharmacol. functions. Goodyeroside A (II), an epimer of kinsenoside, remains less explored. In this report, the authors chem. synthesized kinsenoside, goodyeroside A and their analogs with glycan variation, chirality inversion at chiral center(s), and bioisosteric replacement of lactone with lactam. Among these compounds, goodyeroside A and its mannosyl counterpart III demonstrated superior anti-inflammatory efficacy. Furthermore, goodyeroside A was found to suppress inflammation through inhibiting the NF-κB signal pathway effectively. The structure-activity relationship is also explored for further development of more promising kinsenoside analogs as drug candidates.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The Absolute Best Science Experiment for 34941-92-9

From this literature《The reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions》,we know some information about this compound(34941-92-9)Safety of 4-Chloro-2-fluoropyridine, but this is not all information, there are many literatures related to this compound(34941-92-9).

Safety of 4-Chloro-2-fluoropyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about The reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions. Author is Schlosser, Manfred; Rausis, Thierry.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

From this literature《The reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions》,we know some information about this compound(34941-92-9)Safety of 4-Chloro-2-fluoropyridine, but this is not all information, there are many literatures related to this compound(34941-92-9).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem