Discovery of 52208-50-1

In some applications, this compound(52208-50-1)Quality Control of 2,6-Dichloro-3-fluoropyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called 2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors, published in 2016-03-10, which mentions a compound: 52208-50-1, Name is 2,6-Dichloro-3-fluoropyridine, Molecular C5H2Cl2FN, Quality Control of 2,6-Dichloro-3-fluoropyridine.

New non-nucleoside reverse transcriptase inhibitors (NNRTI), which are similar in structure to earlier described di(arylamino)pyrimidines but featuring a 2,6-di(arylamino)-3-fluoropyridine, 2,4-di(arylamino)-5-fluoropyrimidine, or 1,3-di(arylamino)-4-fluorobenzene moiety instead of a 2,4-disubstituted pyrimidine moiety, are reported. The short and practical synthesis of novel NNRTI relies on two sequential Pd-catalyzed aminations as the key steps. It is demonstrated through direct comparison with reference compounds that the presence of a fluorine atom increases the in vitro anti-HIV activity, both against the wild type virus and drug-resistant mutant strains. Three compounds, e.g., I, were found to display E50 close to 1.0 nM and a very high selectivity index (>40000).

In some applications, this compound(52208-50-1)Quality Control of 2,6-Dichloro-3-fluoropyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem