Formula: C5H2Cl2FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,6-Dichloro-3-fluoropyridine, is researched, Molecular C5H2Cl2FN, CAS is 52208-50-1, about New synthesis method of 2,6-dichloro-3-fluoropyridine. Author is Yang, Weiqing; Lin, Yicheng; Wang, Xiaoning.
2, 6-Dichloro-3-nitropyridine was synthesized from 2, 6-dichloropyridine by nitrification reaction. Then 2,6-dichloro-3-aminopyridine was synthesized from 2,6-dichloro-3-nitropyridine by the catalytic hydrogenation reduction reaction. At last, 2,6-dichloro-3-fluoropyridine was synthesized from 2,6-dichloro-3-aminopyridine by the diazotization reaction. Overall yield of three steps reaction was 69.3%. The target compound was confirmed by MS and NMR. The factors such as nitric acid concentration, the type and amount of catalyst and the molar ratio of sodium nitrite were discussed in detail. This synthesis route has high yield, high selectivity, and better prospect of industrialization.
In some applications, this compound(52208-50-1)Formula: C5H2Cl2FN is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem