Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of Medicinal Chemistry called 2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors, Author is Sergeyev, Sergey; Yadav, Ashok Kumar; Franck, Philippe; Michiels, Johan; Lewi, Paul; Heeres, Jan; Vanham, Guido; Arien, Kevin K.; Vande Velde, Christophe M. L.; De Winter, Hans; Maes, Bert U. W., which mentions a compound: 52208-50-1, SMILESS is ClC1=NC(=CC=C1F)Cl, Molecular C5H2Cl2FN, Formula: C5H2Cl2FN.
New non-nucleoside reverse transcriptase inhibitors (NNRTI), which are similar in structure to earlier described di(arylamino)pyrimidines but featuring a 2,6-di(arylamino)-3-fluoropyridine, 2,4-di(arylamino)-5-fluoropyrimidine, or 1,3-di(arylamino)-4-fluorobenzene moiety instead of a 2,4-disubstituted pyrimidine moiety, are reported. The short and practical synthesis of novel NNRTI relies on two sequential Pd-catalyzed aminations as the key steps. It is demonstrated through direct comparison with reference compounds that the presence of a fluorine atom increases the in vitro anti-HIV activity, both against the wild type virus and drug-resistant mutant strains. Three compounds, e.g., I, were found to display E50 close to 1.0 nM and a very high selectivity index (>40000).
Here is a brief introduction to this compound(52208-50-1)Formula: C5H2Cl2FN, if you want to know about other compounds related to this compound(52208-50-1), you can read my other articles.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem