Synthetic Route of C9H9NO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2-Methylbenzo[d]oxazol-5-yl)methanol, is researched, Molecular C9H9NO2, CAS is 136663-38-2, about Design, synthesis and antimicrobial activity of novel 2-substituted benzoxazole derivatives. Author is Balaswamy, G.; Pradeep, P.; Srinivas, K.; Rajakomuraiah, T..
In the current research work, the title compounds were synthesized from Me 2-substituted benzoxazole-5-carboxylate by refluxing with methanol and THF (1 : 1) in presence of NaBH4, which afforded (2-substituted benzoxazol-5-yl)methanol, on partial oxidation with PCC furnished 2-substituted benzoxazole-5-carbaldehyde, on treatment with appropriate carbonyl compounds monoethyl malonate, Et acetoacetate or malonic acid yielded the corresponding α,β-unsaturated derivatives of 2-substituted benzoxazoles like, Et 3-(2-substituted benzoxazol-5-yl)acrylate, 4-(2-substituted benzoxazol-5-yl)but-3-en-2-one and 3-(2-substituted benzoxazol-5-yl)acrylic acid. The identification and characterization of all the synthesized compounds were confirmed by elemental anal., m.p., thin layer chromatog., FTIR, 1H NMR and mass spectral data. All the compounds were screened for antimicrobial activity. In view of interesting biol. activities and pharmacol. importance associated with benzoxazole derivatives, some of the derivatives of benzoxazole containing heterocyclic ring were prepared and their bio-potential were evaluated.
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Reference:
Pyrroline – Wikipedia,
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