Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 34941-92-9, is researched, Molecular C5H3ClFN, about One-Pot Approach for SNAr Reaction of Fluoroaromatic Compounds with Cyclopropanol, the main research direction is aryl cyclopropyl ether preparation; fluoroarom compound cyclopropanol nucleophilic aromatic substitution.Computed Properties of C5H3ClFN.
A novel method for preparation of aryl cyclopropyl ethers I [Ar = 1-ClC6H4, 2-O2NC6H4, 4-chloro-2-pyridyl, etc.] via nucleophilic aromatic substitution reaction (SNAr) of fluoroarom. compounds with cyclopropanol under relatively mild conditions was developed. The reaction was performed at 75 °C with Cs2CO3 as the base and DMF as solvent, after 6 h the yield was up to 90%. Finally, various fluoroarom. compounds were employed as substrates for a test that proved a wide application scope of the method.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem