Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Total Synthesis of (-)-Maximiscin, Author is McClymont, Kyle S.; Wang, Feng-Yuan; Minakar, Amin; Baran, Phil S., the main research direction is maximiscin enantioselective total synthesis.Name: 4-Chloro-2-fluoropyridine.
A short, enantioselective synthesis of (-)-maximiscin (I), a structurally intriguing metabolite of mixed biosynthetic origin, is reported. A retrosynthetic anal. predicated on maximizing ideality and efficiency led to several unusual disconnections and tactics. Formation of the central highly oxidized pyridone ring through a convergent coupling at the end of the synthesis simplified the route considerably. The requisite building blocks could be prepared from feedstock materials (derived from shikimate and mesitylene). Strategies rooted in hidden symmetry recognition, C-H functionalization, and radical retrosynthesis played key roles in developing this concise route.
In addition to the literature in the link below, there is a lot of literature about this compound(4-Chloro-2-fluoropyridine)Name: 4-Chloro-2-fluoropyridine, illustrating the importance and wide applicability of this compound(34941-92-9).
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem