So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hou, Jinsong; Yang, Gaosheng; Chai, Zhuo researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Reference of 4-Methoxypiperidine.They published the article 《Lanthanide-Catalyzed Tandem Addition of Amines to Cyanoalkenes: Synthesis of Cyclic Amidines》 about this compound( cas:4045-24-3 ) in Journal of Organic Chemistry. Keywords: cyclic amidine preparation diastereoselective; cyanoalkene amine tandem addition cyclization reaction lanthanide catalyst. We’ll tell you more about this compound (cas:4045-24-3).
A tandem insertion of aliphatic nitriles and unactivated alkenes RCH(CN)CH2C(R1)=C(R2)R3 (R = Ph, 2-thienyl, 3-pyridinyl, etc.; R1 = H, Me; R2 = H, Me, Ph, 2-naphthyl, etc.; R3 = H, Me) to the N-H bond of secondary aliphatic amines such as dibenzylamine, pyrrolidine, thiomorpholine, etc. catalyzed by simple trialkyl rare-earth metal complexes was disclosed. This reaction provides a highly atom-economic and stereoselective way to a range of cyclic amidines I (R4 = benzyl(methyl)aminyl, tetrahydroisoquinolin-2-yl, thiomorpholin-4-yl, etc.) under mild reaction conditions.
In addition to the literature in the link below, there is a lot of literature about this compound(4-Methoxypiperidine)Reference of 4-Methoxypiperidine, illustrating the importance and wide applicability of this compound(4045-24-3).
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem