Shaw, Megan H.; Shurtleff, Valerie W.; Terrett, Jack A.; Cuthbertson, James D.; MacMillan, David W. C. published an article about the compound: 4-Chloro-2-fluoropyridine( cas:34941-92-9,SMILESS:ClC1=CC(=NC=C1)F ).Quality Control of 4-Chloro-2-fluoropyridine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:34941-92-9) through the article.
The use of sp3 C-H bonds-which are ubiquitous in organic mols.-as latent nucleophile equivalent for transition metal-catalyzed cross-coupling reactions has the potential to substantially streamline synthetic efforts in organic chem. while bypassing substrate activation steps. Through the combination of photoredox-mediated hydrogen atom transfer (HAT) and nickel catalysis, we have developed a highly selective and general C-H arylation protocol that activates a wide array of C-H bonds as native functional handles for cross-coupling. This mild approach takes advantage of a tunable HAT catalyst that exhibits predictable reactivity patterns based on enthalpic and bond polarity considerations to selectively functionalize α-amino and α-oxy sp3 C-H bonds in both cyclic and acyclic systems.
In addition to the literature in the link below, there is a lot of literature about this compound(4-Chloro-2-fluoropyridine)Quality Control of 4-Chloro-2-fluoropyridine, illustrating the importance and wide applicability of this compound(34941-92-9).
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem