Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-5-iodo-3-methylpyridine, is researched, Molecular C6H5ClIN, CAS is 59782-89-7, about An improved procedure for the oxidation of 2,5- and 5,6-dihalo-3-methylpyridines.HPLC of Formula: 59782-89-7.
Nicotinic acids I (R = Br, Cl, F; R1 = iodo, Br, Cl) were obtained from methylpyridines II and Bu4N+ MnO4-. Similarly prepared were acids III (R2 = Br, Cl). 5,6-Dibromo-3-methylpyridine in pyridine was oxidized by Bu4N+ MnO4- at 75-80° to give III (R2 = Br).
In addition to the literature in the link below, there is a lot of literature about this compound(2-Chloro-5-iodo-3-methylpyridine)HPLC of Formula: 59782-89-7, illustrating the importance and wide applicability of this compound(59782-89-7).
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem