In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy, published in 2021-04-08, which mentions a compound: 34941-92-9, mainly applied to AM0902 oxadiazolone azabicyclohexane THF synthesis TRPA1 inflammation asthma pain, Computed Properties of C5H3ClFN.
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interest as a target for inhibition due to its implication in neuropathic pain and respiratory disease. Herein, we describe the optimization of a series of potent, selective, and orally bioavailable TRPA1 small mol. antagonists, leading to the discovery of a novel tetrahydrofuran-based linker. Given the balance of physicochem. properties and strong in vivo target engagement in a rat AITC-induced pain assay, compound (I) was progressed into a guinea pig ovalbumin asthma model where it exhibited significant dose-dependent reduction of inflammatory response. Furthermore, the structure of the TRPA1 channel bound to compound (II) was determined via cryogenic electron microscopy to a resolution of 3 Å, revealing the binding site and mechanism of action for this class of antagonists. Tetrahydrofurans
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem