The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2-Methylbenzo[d]oxazol-5-yl)methanol( cas:136663-38-2 ) is researched.Formula: C9H9NO2.Balaswamy, G.; Pradeep, P.; Srinivas, K.; Rajakomuraiah, T. published the article 《Design, synthesis and antimicrobial activity of novel 2-substituted benzoxazole derivatives》 about this compound( cas:136663-38-2 ) in International Journal of Chemical Sciences. Keywords: benzoxazole derivative preparation antimicrobial activity. Let’s learn more about this compound (cas:136663-38-2).
In the current research work, the title compounds were synthesized from Me 2-substituted benzoxazole-5-carboxylate by refluxing with methanol and THF (1 : 1) in presence of NaBH4, which afforded (2-substituted benzoxazol-5-yl)methanol, on partial oxidation with PCC furnished 2-substituted benzoxazole-5-carbaldehyde, on treatment with appropriate carbonyl compounds monoethyl malonate, Et acetoacetate or malonic acid yielded the corresponding α,β-unsaturated derivatives of 2-substituted benzoxazoles like, Et 3-(2-substituted benzoxazol-5-yl)acrylate, 4-(2-substituted benzoxazol-5-yl)but-3-en-2-one and 3-(2-substituted benzoxazol-5-yl)acrylic acid. The identification and characterization of all the synthesized compounds were confirmed by elemental anal., m.p., thin layer chromatog., FTIR, 1H NMR and mass spectral data. All the compounds were screened for antimicrobial activity. In view of interesting biol. activities and pharmacol. importance associated with benzoxazole derivatives, some of the derivatives of benzoxazole containing heterocyclic ring were prepared and their bio-potential were evaluated.
As far as I know, this compound(136663-38-2)Formula: C9H9NO2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem