Application In Synthesis of 4-Chloro-2-fluoropyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about Selective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction. Author is Fier, Patrick S.; Hartwig, John F..
Fluorinated heterocycles are prevalent in pharmaceuticals, agrochems., and materials. However, reactions that incorporate fluorine into heteroarenes are limited in scope and can be hazardous. The authors present a broadly applicable and safe method for the site-selective fluorination of a single carbon-hydrogen bond in pyridines and diazines using com. available silver(II) fluoride. The reactions occur at ambient temperature within 1 h with exclusive selectivity for fluorination adjacent to nitrogen. The mild conditions allow access to fluorinated derivatives of medicinally important compounds, as well as a range of 2-substituted pyridines prepared by subsequent nucleophilic displacement of fluoride. Mechanistic studies demonstrate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a broad range of nitrogen heterocycles.
Although many compounds look similar to this compound(34941-92-9)Application In Synthesis of 4-Chloro-2-fluoropyridine, numerous studies have shown that this compound(SMILES:ClC1=CC(=NC=C1)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem