So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Seebach, Dieter; Eberle, Martin researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one.They published the article 《(R)-Ethyl 4-tert-butoxy-3-hydroxybutanoate, a versatile chiral building block for EPC (enantiomerically pure compound) syntheses, by yeast reduction of ethyl 4-tert-butoxy-3-oxobutanoate》 about this compound( cas:58081-05-3 ) in Synthesis. Keywords: butoxyoxobutanoate stereoselective reduction yeast; butoxyhydroxybutanoate; chiral hydroxy ester preparation. We’ll tell you more about this compound (cas:58081-05-3).
Treatment of ROCH2COCH2CO2R1 (I; R = Me3C, R1 = Et) with baker’s yeast and sucrose in H2O at 28° for 4 days gave 72% (R)-ROCH2CH(OH)CH2CO2R1 (II; R = Me3C, R1 = Et) in 97% enantiomeric excess. Similar treatment of I (R = Me3C, R1 = Me; R = PhCH2, R1 = Et) gave 70 and 58% II in 82 and 56% enantiomeric excess resp.
Although many compounds look similar to this compound(58081-05-3)Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one, numerous studies have shown that this compound(SMILES:O=C1OC[C@H](O)C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem