In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of nature product kinsenoside analogues with anti-inflammatory activity, published in 2021-01-01, which mentions a compound: 58081-05-3, mainly applied to kinsenoside analog preparation antiinflammatory structure activity; goodyeroside A analog preparation antiinflammatory structure activity; Anti-inflammatory; Goodyeroside A; Kinsenoside; Nitric Oxide Release; Structure-activity Relationship, Application In Synthesis of (R)-4-Hydroxydihydrofuran-2(3H)-one.
Kinsenoside (I) is a major bioactive component in herbal medicines that possesses a broad range of pharmacol. functions. Goodyeroside A (II), an epimer of kinsenoside, remains less explored. In this report, the authors chem. synthesized kinsenoside, goodyeroside A and their analogs with glycan variation, chirality inversion at chiral center(s), and bioisosteric replacement of lactone with lactam. Among these compounds, goodyeroside A and its mannosyl counterpart III demonstrated superior anti-inflammatory efficacy. Furthermore, goodyeroside A was found to suppress inflammation through inhibiting the NF-κB signal pathway effectively. The structure-activity relationship is also explored for further development of more promising kinsenoside analogs as drug candidates.
After consulting a lot of data, we found that this compound(58081-05-3)Application In Synthesis of (R)-4-Hydroxydihydrofuran-2(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem