The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Lanthanide-Catalyzed Tandem Addition of Amines to Cyanoalkenes: Synthesis of Cyclic Amidines》. Authors are Hou, Jinsong; Yang, Gaosheng; Chai, Zhuo.The article about the compound:4-Methoxypiperidinecas:4045-24-3,SMILESS:COC1CCNCC1).Related Products of 4045-24-3. Through the article, more information about this compound (cas:4045-24-3) is conveyed.
A tandem insertion of aliphatic nitriles and unactivated alkenes RCH(CN)CH2C(R1)=C(R2)R3 (R = Ph, 2-thienyl, 3-pyridinyl, etc.; R1 = H, Me; R2 = H, Me, Ph, 2-naphthyl, etc.; R3 = H, Me) to the N-H bond of secondary aliphatic amines such as dibenzylamine, pyrrolidine, thiomorpholine, etc. catalyzed by simple trialkyl rare-earth metal complexes was disclosed. This reaction provides a highly atom-economic and stereoselective way to a range of cyclic amidines I (R4 = benzyl(methyl)aminyl, tetrahydroisoquinolin-2-yl, thiomorpholin-4-yl, etc.) under mild reaction conditions.
After consulting a lot of data, we found that this compound(4045-24-3)Related Products of 4045-24-3 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem