The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ) is researched.Safety of (R)-4-Hydroxydihydrofuran-2(3H)-one.Dostie, Starr; Prevost, Michel; Mochirian, Philippe; Tanveer, Kashif; Andrella, Nicholas; Rostami, Ariana; Tambutet, Guillaume; Guindon, Yvan published the article 《Diastereoselective Synthesis of C2′-Fluorinated Nucleoside Analogues Using an Acyclic Approach》 about this compound( cas:58081-05-3 ) in Journal of Organic Chemistry. Keywords: C fluorinated nucleoside analog diastereoselective synthesis cyclization acyclic thioaminal. Let’s learn more about this compound (cas:58081-05-3).
Nucleoside analogs bearing a fluorine in the C2′-position have been synthesized by SN2-like cyclizations of acyclic thioaminal precursors. This strategy provides access to two scaffolds, D-1′,2′-cis-thiofuranosides and D-1′,2′-trans-furanosides, which are difficult to generate using the standard approach for nucleoside synthesis. The addition of silylated nucleobases onto model C2-fluorinated dithioacetal substrates resulted in 1,2-syn diastereoselectivity, which is consistent with the C2-F and S-alkyl moiety being in close proximity. A new series of analogs bearing a C3′ all-carbon quaternary center along with a C2′-F atom have also been synthesized using this approach and are being investigated as potential antimetabolites.
After consulting a lot of data, we found that this compound(58081-05-3)Safety of (R)-4-Hydroxydihydrofuran-2(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem