In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer, published in 2021-01-15, which mentions a compound: 4045-24-3, mainly applied to pyrimidine human colorectal cancer anticancer apoptosis; AMP-Activated protein kinase (AMPK); Colorectal cancer; NUAK; WZ4003 derivatives, COA of Formula: C6H13NO.
NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhibitor WZ4003, a series of derivatives has been synthesized and evaluated for anticancer activity. Compound I, a derivative of WZ4003 by removing a methoxy group, was found to be the most potential one with stronger inhibitory against NUAK1/2 enzyme activity, tumor cell proliferation and inducing apoptosis of tumor cells. By in vivo efficacy evaluations of colorectal SW480 xenografts, I suppresses tumor growth more effectively with an excellent safety profile in vivo and is therefore seen as a suitable candidate for further investigation.
The article 《Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer》 also mentions many details about this compound(4045-24-3)COA of Formula: C6H13NO, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem