So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kabeche, Stephanie; Aida, Jumpei; Akther, Thamina; Ichikawa, Takashi; Ochida, Atsuko; Pulkoski-Gross, Michael J.; Smith, Mark; Humphries, Paul S.; Yeh, Ellen researched the compound: 4-Methoxypiperidine( cas:4045-24-3 ).Product Details of 4045-24-3.They published the article 《Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS》 about this compound( cas:4045-24-3 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: azepanylpropyl azaheterocyclylalkyl arylthiazolecarboxamide heteroarylcarboxamide preparation antimalarial agent; structure azaheterocyclylalkyl arylthiazolecarboxamide inhibition malarial farnesyldiphosphate geranylgeranyldiphosphate synthase; lipophilicity solubility biol permeation metabolism antimalarial activity azepanylpropyl arylthiazolecarboxamide; Farnesyl/Geranylgeranyl diphosphate synthase; Malaria; Plasmodium falciparum; SAR; Thiazole. We’ll tell you more about this compound (cas:4045-24-3).
A series of novel thiazole-containing amides such as I.TFA were synthesized as inhibitors of Plasmodium falciparum farnesyldiphosphate synthase (PfFPPS) and geranylgeranyldiphosphate synthase (PfGGPPS). A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising candidate mols. were progressed to mouse in vivo PK studies and demonstrated adequate free drug exposure to warrant further investigation.
Different reactions of this compound(4-Methoxypiperidine)Product Details of 4045-24-3 require different conditions, so the reaction conditions are very important.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem