The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ) is researched.Product Details of 58081-05-3.Wang, Yanfang; Li, Jincui; Wu, Yulin published the article 《Synthesis of 11-C-20-C segment of leukotriene B4 and migration of silyl protecting group》 about this compound( cas:58081-05-3 ) in Huaxue Xuebao. Keywords: leukotriene B4 segment hydroxydecenal; silyloxyhydroxytetrahydrofuran Wittig silyl migration. Let’s learn more about this compound (cas:58081-05-3).
A new synthesis of 11-C-20-C segment of leukotriene B4, 2(R)-hydroxydec-4(Z)-enal derivatives I (R = SiPh2CMe3, SiMe2CMe3, CPh3) using ascorbic acid as chiron is described. A partial or full migration of silyl protecting group from a secondary hydroxy group to a vicinal primary one is discovered in the Wittig reaction of hemiacetals II (R1 = SiPh2CMe3, SiMe2CMe3) with Me(CH2)5P+Ph3Br-.
Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Product Details of 58081-05-3 require different conditions, so the reaction conditions are very important.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem