Month: August 2023

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Copper-Catalyzed 3-Positional Amination of 2-Azulenols with O-Benzoylhydroxylamines, published in 2021-09-03, which mentions a compound: 4045-24-3, mainly applied to azulenol benzoylhydroxylamine copper catalyst regioselective amination; aminoazulenol preparation, Related Products of 4045-24-3.

A copper-catalyzed ortho-selective amination of 2-azulenols with O-benzoylhydroxylamines (RR’N-OBz) to synthesize ortho-aminoazulenols was reported. A wide range of functional groups on amines were compatible, furnishing the corresponding amino-azulene derivatives in moderate to good yields. The further synthetic elaboration using 3-amino-2-azulenols as starting materials was demonstrated.

Different reactions of this compound(4-Methoxypiperidine)Related Products of 4045-24-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Formula: C4H6O3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about A novel total synthesis of kinsenoside and goodyeroside A relying on the efficient reaction of the chiral 2(5H)-furanones.

A new total synthesis of the bioactive compounds, kinsenoside (I; R1 = H) and goodyeroside A (II; R2 = H), has been accomplished from readily available starting materials. The chiral 2(5H)-furanone III and its enantiomer IV were employed as the key chiral intermediates to construct the chiral glycosides V and VI with the appropriate stereochem. The spectral data of the target compounds and their acetylated derivatives (I; R1 = Ac) and (II; R2 = Ac) are identical with those of the natural and corresponding acetylated products.

《A novel total synthesis of kinsenoside and goodyeroside A relying on the efficient reaction of the chiral 2(5H)-furanones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Formula: C4H6O3.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem