In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enantiomerically pure β,γ-epoxyesters from β-hydroxylactones: synthesis of β-hydroxyesters and (-)-GABOB, published in 1990, which mentions a compound: 58081-05-3, mainly applied to hydroxybutanolide ring cleavage iodotrimethylsilane; iodohydrin cyclization silver oxide; epoxy ester preparation alkylation cuprate; hydroxy ester, Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one.
The preparation of enantiomerically pure β,γ-epoxy esters was achieved by chemoselective opening of β-hydroxybutanolides with Me3SiI followed by cyclization of the resulting iodohydrins with Ag2O. The reaction of these epoxy esters with lithio- or magnesiocuprates afforded stereochemically pure α-substituted-β-hydroxy esters. Alternatively, the title compound, (R)-H2NCH2CH(OH)CH2CO2H, was synthesized in optically pure form from the iodohydrin (R)-ICH2CH(OH)CH2CO2Et.
《Enantiomerically pure β,γ-epoxyesters from β-hydroxylactones: synthesis of β-hydroxyesters and (-)-GABOB》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem