Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Angewandte Chemie, International Edition called C-O Cross-Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols, Author is Maligres, Peter E.; Li, Jing; Krska, Shane W.; Schreier, John D.; Raheem, Izzat T., the main research direction is palladium catalyst alkoxylation aryl heteroaryl halide alc; aromatic ether preparation.SDS of cas: 34941-92-9.
The authors describe a Pd/Josiphos catatyst system for alkoxylation of activated aryl and heteroaryl halides with primary, secondary, and select tertiary alcs. E.g., in presence of [Pd2(dba)3] and ligand CyPF-tBu (I), C-O cross-coupling of 4-chloro-2-methylquinoline and PhCH2CH2OH gave 99% aromatic ether 4-(2-phenylethoxy)-2-methylquinoline.
Different reactions of this compound(4-Chloro-2-fluoropyridine)SDS of cas: 34941-92-9 require different conditions, so the reaction conditions are very important.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem