Introduction of a new synthetic route about 58081-05-3

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)HPLC of Formula: 58081-05-3 require different conditions, so the reaction conditions are very important.

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ) is researched.HPLC of Formula: 58081-05-3.Zhang, Yang; Xia, Yihong; Lai, Yongji; Tang, Fang; Luo, Zengwei; Xue, Yongbo; Yao, Guangmin; Zhang, Yonghui; Zhang, Jinwen published the article 《Efficient synthesis of kinsenoside and goodyeroside A by a chemo-enzymatic approach》 about this compound( cas:58081-05-3 ) in Molecules. Keywords: kinsenoside chemoenzymic synthesis; goodyeroside chemoenzymic synthesis. Let’s learn more about this compound (cas:58081-05-3).

Kinsenoside (1) and goodyeroside A (2), two naturally occurring stereoisomers with diverse biol. activities, have been synthesized efficiently by a chemo-enzymic approach with a total yield of 12.7%. The aglycons, (R)- and (S)-3-hydroxy-γ-butyrolactone, were prepared from d- and l-malic acid by a four-step chem. approach with a yield of 75%, resp. These butyrolactones were then successfully glycosidated using β-D-glucosidase as a catalyst in a homogeneous organic-water system. Under the optimized enzymic conditions, the yields of kinsenoside and goodyeroside A in the enzymic steps both reached 16.8%.

Different reactions of this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)HPLC of Formula: 58081-05-3 require different conditions, so the reaction conditions are very important.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem