#REF!
Synthetic Studies on Cyclocitrinol: Construction of the ABC Ring System Based on Epoxy-Nitrile Cyclization
The stereoselective synthesis of a model compound containing the ABC ring system of cyclocitrinol was accomplished. After connecting a C ring allyltitanium segment with an A ring bi-cyclo[4.1.0]heptanone segment, the seven-membered B ring moiety was constructed by an intramolecular cyclization reaction of an epoxy nitrile. The enone moiety was introduced through an oxidative decyanation reaction, and the bicyclo[4.4.1]undecane skeleton with the highly strained olefin moiety was formed through a ring-opening reaction of the bicyclo[4.1.0]heptane substructure.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem