Chemistry, like all the natural sciences, Formula: C5H7N, begins with the direct observation of nature¡ª in this case, of matter.636-41-9, Name is 2-Methyl-1H-pyrrole, SMILES is CC1=CC=CN1, belongs to pyrrolines compound. In a document, author is Wolinski, Przemyslaw, introduce the new discover.
Clean and molecularly programmable protocol for preparation of bis-heterobiarylic systems via a domino pseudocyclic reaction as a valuable alternative for TM-catalyzed cross-couplings
The domino sequence of pseudocyclic reactions involving 4-methoxybenzonitrile N-oxide and trans-2-phenyl-1-cyano-1-nitroethene proceeding in mild (r.t.; atm. pressure) non-catalytic (without participation of palladium or other transition metals (TM)) conditions yielded a bis-heterobiarylic molecular system containing an oxadiazole moiety with an almost 40% yield. The presented methodology represents therefore an evident contrast to the existing methods of preparation of bis-heterobiarylic systems, which require the presence of TMs. This reaction should be considered stereochemically clean and contains a stage of cycloaddition to the C=N bond. It should be underlined that this is the first case of non-catalyzed [3 + 2] cycloaddition involving the nitrile C=N bond. Our comprehensive study shows that the described protocol can be applied as a general methodology for preparation of a wide group of bis-heterobiarylic molecules. The self-adjusted cascade of transformations, which is unique and valuable from the practical point of view, leads to formation of a single isomeric product (from many possible) as a consequence of three pseudocyclic tandem reactions performed in agreement with the fundamental principles of green chemistry and sustainable development with a maximal level of atom economy and good overall yields. A self-adjustment phenomenon observed in the studied smart technology leading to production of a material with special properties was explained by it deep quantum nature confirmed undoubtedly by the modern Molecular Electron Density Theory. (C) 2020 Elsevier Ltd. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 636-41-9. Formula: C5H7N.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem