Let¡¯s face it, organic chemistry can seem difficult to learn, Recommanded Product: 4-(2-Aminoethyl)aniline, Especially from a beginner¡¯s point of view. Like 13472-00-9, Name is 4-(2-Aminoethyl)aniline, molecular formula is pyrrolines, belongs to pyrrolines compound. In a document, author is Shee, Maniklal, introducing its new discovery.
Photocatalytic Conversion of Benzyl Alcohols/Methyl Arenes to Aryl Nitriles via H-Abstraction by Azide Radical
This report presents the visible-light-assisted synthesis of aryl nitriles from easily accessible alcohols or methyl arenes in the presence of O-2. Organic photoredox catalyst, 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene), induces single electron transfer (SET) from azide N(3)(-)and generates azide radical N-3(.).The photogenerated N(3)(.)abstracts H atom from alpha-C-H bond of benzylic system, which provides aldehyde and hydrazoic acid (HN3) in situ. This reaction subsequently forms azido alcohol intermediate that transforms into nitrile with the assistance of triflic acid (Bronsted acid). A range of alcohols and methyl arenes successfully underwent cyanation at room temperature with good to excellent yields and showed good functional group tolerance.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem