Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 7423-55-4, Name is 3-Maleimidopropionic acid, molecular formula is , belongs to pyrrolines compound. In a document, author is Rodriguez-Soria, Veronica, Formula: C7H7NO4.
A novel stereoselective tin-free radical protocol for the enantioselective synthesis of pyrrolidinones and its application to the synthesis of biologically active GABA-derivatives
Optically pure 4-alkyl-pyrrolin-2-ones were synthesized from chiral N-allyl-alpha-bromoacetamides in high selective and stereo-controlled fashion, via a sequential 5-exo-trig radical cyclization-hydrogen or bromine atom-transfer process, under non-tin conditions. Interestingly, when N-allyl-alpha-bromoacetamides were treated with triethylborane/MeOH(excess)/BF3 center dot OEt2 in toluene at -78 degrees C, a tandem 5-exo-trig radical cyclization-hydrogen atom-transfer reaction operated, on the other hand, a tandem 5-evo-trig radical cyclization-bromine atom-transfer reaction proceeded in good yield and high stereoselectivity when the reaction was carried out with equimolar amounts of MeOH in THF at -78 degrees C. Thus, optically pure 4-alkyl-pyrrolin-2-ones were synthesized via this tin-free radical pathway and transformed to their corresponding biologically active GABA-derivatives, Pregabalin and CAMP. (C) 2008 Published by Elsevier Ltd.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 7423-55-4, in my other articles. Formula: C7H7NO4.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem