1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of analogue 2 was undertaken following the procedure of Baker et al.2 Purified amylin-(1-8) (9) (10.0 mg, 12.4 x 10-3 mmol) was dissolved in a deoxygenated mixture of acetonitrile (12.0 mL) and 250 mM potassium phosphate buffer (24.0 mL, pH 7) and was further deoxygenated for 30 min (argon). 2,3-Dibromomaleimide (3.46 mg, 13.59 x 10-3 mmol) was then added and the resulting yellow mixture was stirred at room temperature for 30 min under argon during which time all the starting material had disappeared as judged by analytical RP-HPLC (Figure S 5). Crude product 2 was lyophilised and purified by RP-HPLC on a preparative Waters XTerra Prep. C18 column at a flow rate of 10 mL/min, using a linear gradient of 1%B to 36%B over 23 min (ca. 1.5%B per minute). Fractions were lyophilised to give the title compound 2 as a white amorphous solid (1.7 mg, 15%)., 1122-10-7
The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kowalczyk, Renata; Harris, Paul W.R.; Brimble, Margaret A.; Callon, Karen E.; Watson, Maureen; Cornish, Jillian; Bioorganic and Medicinal Chemistry; vol. 20; 8; (2012); p. 2661 – 2668;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem