Chemical Research Letters, May 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world., Computed Properties of https://www.ambeed.com/products/766-36-9.html, Introducing a new discovery about 766-36-9, Name is 3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one, molecular formula is C7H11NO, belongs to pyrrolines compound. In a document, author is Chavan, Kamlesh H..
Synthesis, molecular modeling and biological evaluations of novel pyrrolidine derivatives as potential cyclooxygenase-2 (COX-2) inhibitors
Toward the development of selective cyclooxygenase-2 inhibitors, a series of pyrrolidine derivatives is described. All the compounds containing sulfonamide, ester, nitrile, acid, amide and urea functionalities were computationally screened, and binding affinity scores for all synthesized compounds with cyclooxygenase-1 and cyclooxygenase -2 were compared. The computational observations showed three top-ranked compounds (8b, 8d and 10a) having selectively more affinity for cyclooxygenase -2. These were selected for pharmacological evaluation using carrageenan-induced rat paw edema model. Compound 8b showed maximum activity (54.83%) which was closer to standard drug indometacin (57.48%). The safety parameter of the potent compound (8b) was assessed using aspirin induced gastric ulceration animal model. [GRAPHIC].
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 766-36-9. Computed Properties of https://www.ambeed.com/products/766-36-9.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem