New research progress on 578-95-0 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 578-95-0, Name is Acridin-9(10H)-one, molecular formula is C13H9NO, belongs to pyrrolines compound, is a common compound. In a patnet, author is Mun, JiYoung, once mentioned the new application about 578-95-0, Quality Control of Acridin-9(10H)-one.
N-benzyl-5-hydroxy-3-pyrrolidin-2-one by hydrogen peroxide oxidation of n-benzyl-3-phenylseleno-2-pyrrolidinone
Using the known peroxide oxidation of N-benzyl-3-phenylseleno-2-pyrrolidinone with 30% hydrogen peroxide at – 5 degrees C after 3.5 h, we prepared the expected N-benzyl-3-pyrrolin-2-one. However, reaction with 30% hydrogen peroxide for 12 h (-5 degrees C -> ambient) gave the unexpected product N-benzyl-5-hydroxy-3-pyrrolidin2-one in 84% isolated yield. This procedure is a new synthetic route to N-benzyl-5hydroxy-3-pyrrolidin-2-one.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem