With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.,541-59-3
Example 9:conversion of an amine to a maleimide moiety /V-(Methoxycarbonyl)maleimide (37) Methyl chloroformate (0.87 ml_, 11.3 mmol) was added slowly to a solution of maleimide (1.00 g, 10.3 mmol) and /V-methyl morpholine (1.24 ml_, 1 1.3 mmol) in EtOAc (80 ml_) at 0 C and stirred for 1 hr. The precipitate was separated out through filtration through a celite pad and the filtrate concentrated in vacuo. It was attempted to recrystallise the crude oil with hexane: CH2CI2 but no crystallisation occurred. The crude product was redissolved in EtOAc (100 ml_), adsorbed onto silica and purified using column chromatography (Hex: EtOAc 6:4) to yield a white solid (1 .07 g, 67%). 5H (CDCI3, 300 MHz): 6.83 (2H, s, CH-3/4), 3.94 (3H, s, CH3-2′) 8c (CDCI3, 100 MHz): 165.6 (C-2/5), 148.1 (C-1 ‘), 132.3 (C-3/4), 54.2 (C-2’)
541-59-3 Maleimide 10935, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; THE SOUTH AFRICAN NUCLEAR ENERGY CORPORATION LIMITED; UNIVERSITY OF CAPE TOWN; DRIVER, Cathryn Helena Stanford; ZEEVAART, Jan Rijn; PARKER, Mohamed Iqbal; HUNTER, Roger; (67 pag.)WO2016/46793; (2016); A2;,
Pyrroline – Wikipedia
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